Week 2 Pathophisiology

1.Which form of cellular adaptation occurs because of decreased work demands on the cell? Explain your answer.

A. Hypertrophy

B. Hyperplasia

C. Atrophy

D. Metaplasia

Write a paragraph from 250-500 words explaining your answer. 

Include at least one reference and citation in paragraph.

You must reply at least to 2 classmates. No limit of words.

1s reply  
Yulianela Quintana Chavez

The loss or wasting of muscle tissue is known as muscular atrophy. An organ or body part that has undergone atrophy may have a decrease in one or both of the component cells’ numbers or sizes. Atrophy is the shrinkage of a tissue, cell, organ, or body portion. That before the reduction, the atrophied portion had a typical size for the person given their age and circumstances. Atrophic states are typically experienced by specific cells and organs at specific ages or in specific physiological conditions. Parts of the female reproductive organs physiologicly decline in tandem with their regular cyclical alterations. If pregnancy has not taken place, the corpus luteum of the ovary atrophies during the monthly cycle. The uterine muscles, which grow throughout pregnancy, quickly shrink after the baby is delivered, while the breast’s milk-producing acinar structures shrink in size once nursing is finished. The uterus, breasts, and ovaries typically experience some degree of atrophic alteration during menopause.Changes in nutrition and the metabolic activity of cells and tissues are linked to atrophy in general. When there is starvation, whether due to a lack of food or an illness preventing it from being ingested and absorbed, there is a widespread or generalized atrophy of body tissues.

Muscle atrophy comes in three flavors: neurogenic, pathologic, and physiologic. Muscle atrophy results from insufficient usage of the muscles. Exercise and improved diet can frequently restore this kind of atrophy. The most impacted are people with sedentary occupations, mobility-impairing medical conditions, or lower levels of activity. are confined to beds. cannot move their limbs due to a brain ailment or stroke. are in an environment devoid of gravity, like space travel. Aging, malnutrition, and illnesses like Cushing’s disease (caused by overuse of corticosteroids) can all produce pathologic atrophy. The most severe kind of muscular loss is called neurogenic atrophy. It may result from a sickness or injury to a nerve that supplies the muscle. Compared to normal atrophy, this kind of muscular atrophy typically happens more quickly. (Medlineplus, 2021)


2nd reply
Saidi Araujo Duque 

Atrophy is a form of cellular adaptation that occurs as a result of reduced work demands on the cell. Atrophy is a form of cellular adaptation that is characterized by a reduction in the size and functionality of the cell. The reduction happens after a reduction in the demand that is placed on the cell (Ebouda, 2024). Typically, when the workload of a cell reduces, atrophy occurs. In the case that cells have a reduction in their workload, they undergo a procedure that revolves around shrinking. Moreover, the cell reduces metabolic activity as a way of saving energy (Ebouda, 2024). In addition, the reduction in the size of the cell is typically attained through the degradation of the cellular organelles and proteins. This leads to a reduction in the overall mass of the tissue.

    For instance, the atrophy of the skeletal muscle may occur when an individual does not engage in any form of physical activity resulting in the diminishing of the strength and size of the muscle fibers. On the other hand, disuse atrophy has the potential to affect other organs and tissues such as the kidneys, heart, and brain (Robinson, 2023). These organs can experience atrophy in situations where they are not subjected to their normal workload. It is essential to note that atrophy is a process that is reversible to some degree. In case the workload is restored, the cells may restore their normal size and functionality. However, in cases of severe or prolonged atrophy, the tissues are irreversible due to damage and dysfunction of the tissues (Robinson, 2023). This calls for the importance of ensuring that the typical level of cellular functionality is maintained. In conclusion, this helps in assuring the functionality and integrity of the tissue. 

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